Emo1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Emo1^C57BL/6J
• Name: emotionality 1; C57BL/6J
• MGI ID: MGI:2154050
• QTL: Emo1 Location: Chr1:162977097-185994196 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 81.08 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased emotionality compared to BALB/cJ. (J:58187)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:58187

Loci associated with emotionality on mouse chromosome 1 and mouse Chromosome 15 were further investigated using haplotype analysis with selected inbred DeFries strains H1, H2, L1, L2, C1, and C2 (H = high activity, L = low activity, C = control). Also, QTL analysis was performed using 71 (H1 X C1)F2 intercross animals. Animals were evaluated using open field activity (OFA) and open field defecation (OFD) tests as a measure of emotionality. Emotionality QTLs Emo1 and Emo2 were confirmed and localized to mouse Chromosome 1 between D1Mit452 and D1Mit361 (P = 0.0006 at approximately 73.9 cM - 87.0 cM) and mouse Chromosome 15 between D15Mit105 and D15Mit68 (P = 0.0038 at approximately 44.1 cM - 47.9 cM).

References

• Original: J:58187 Turri MG, et al., High-resolution mapping of quantitative trait loci for emotionality in selected strains of mice. Mamm Genome. 1999 Nov;10(11):1098-101
• All: 1 reference(s)