Exq2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Exq2^C57BL/6J
• Name: exploratory and excitability QTL 2; C57BL/6J
• MGI ID: MGI:2154084
• QTL: Exq2 Location: Chr1:135099720-135099816 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 58.27 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:44650

Parental strains (A/J x C57BL/6J) and their F1 and 518 F2 intercross offspring were assessed for their fear-like behaviors in open field behavior tests. Parental strain C57BL/6J exhibits increased light-dark transitions and increased center time in an open field compared to parental strain A/J. Whole genome scan using 114 polymorphic markers indicated the presence of 2 distinct non-overlapping quantitative trait loci (QTLs) on mouse Chromosome 1 at 70 cM (Exq2, LOD = 7.7 at D1Mit445) and at 37 cM (Exq3, LOD = 3.97 at D1Mit435). Exq2 is linked to initial center time in an open field and Exq3 is linked to trial 1 average center time in an open field.

A suggestive locus mapped to 49 cM on mouse Chromosome X with LOD = 2.84 at DXMit172. This locus is associated with LD transitions during the third LD transition trial (LD3) but not the first or second.

References

• Original: J:44650 Gershenfeld HK, et al., Mapping quantitative trait loci for fear-like behaviors in mice. Genomics. 1997 Nov 15;46(1):1-8
• All: 1 reference(s)