Mors1^BALB/cJ
QTL Variant Detail

Summary

• QTL variant: Mors1^BALB/cJ
• Name: modifier of obesity related sterility 1; BALB/cJ
• MGI ID: MGI:2154245
• QTL: Mors1 Location: Chr1:187379500-187379618 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 91.86 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BALB/cJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased sterility in male animals compared to C57BL/6J. (J:52903)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mors1 exhibits an additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52903

130 polymorphic markers at an average spacing of 10.4 cM were screened in a population of obese (C57BL/6J-Lep^ob/Lep^ob x BALB/cJ)F2 male and female animals to identify loci modifying obesity related sterility. C57BL/6J-Lep^ob/Lep^ob animals are obese and infertile whereas BALB/cJ animals are lean and fertile. Continuous treatment with leptin is able to alleviate infertility in C57BL/6J-Lep^ob/Lep^ob animals. (C57BL/6J-Lep^ob/Lep^ob x BALB/cJ)F2 animals were assessed for fertility in the absence of leptin treatment and subjected to full genome scan analysis. Loci on mouse chromosome 1, 3, and 14 were shown to be associated with fertility in obese F2 male mice. Mors1 (modifier of obesity related sterility) mapped to mouse chromosome 1 from 101.5 cM - 106.3 cM in association with fertility (ability to induce pregnancy in lean C57BL/6J females). Mors1 gave a LOD = 5.6 at D1Mit459 and exhibits an additive mode of inheritance. Suggestive loci for fertility mapped to mouse chromosome 3 (LOD = 2.4 at D3Mit316) and mouse chromosome 9 (LOD = 2.7 at D9Mit297). Mors2, a locus associated with testes weight/body weight (TW/BW) ratio mapped to mouse chromosome 3 from 52.5 cM - 71.8 cM with a LOD = 3.4 at D3Mit316. It was observed that fertile obese F2 male animals inherit a greater proportion of BALB/cJ-derived alleles at Mors1 and Mors2 compared to nonfertile obese F2 male animals. Loci associated with absolute testosterone levels, Mors3 and Mors4, mapped to mouse chromosome 14 from 27.5 cM - 30.0 cM and 15.0cM - 27.5 cM, respectively, and exhibit recessive inheritance. Mors3 gives a peak LOD = 3.8 at D14Mit113, and Mors4 gives a peak LOD = 3.4 at D14Mit203. A locus associated with body weight in obese males, Bwob, mapped to mouse chromosome 5 from 34 cM - 68cM with a peak LOD = 5 at D5Mit271 and exhibits recessive inheritance.

References

• Original: J:52903 Ewart-Toland A, et al., Effect of the genetic background on the reproduction of leptin-deficient obese mice. Endocrinology. 1999 Feb;140(2):732-8
• All: 1 reference(s)