Nidd6^BALB/cA
QTL Variant Detail

Summary

• QTL variant: Nidd6^BALB/cA
• Name: non-insulin-dependent diabetes mellitus 6; BALB/cA
• MGI ID: MGI:2154248
• QTL: Nidd6 Location: unknown Genetic Position: Chr1, cM position of peak correlated region/allele: 65.11 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BALB/cA

Variant description

• Allele Type: QTL
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Candidate Genes

J:99477

Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes.

A potential candidate gene for Obq2 at 15 cM on mouse Chromosome 1 as identified by ExQuest is Gsta3. For QTLs Obq7 (28.7 cM), Wt6q1 (27 cM), Insq2 (36cM), and Insq6 (37 cM), potential candidate genes Aox1 (23.2 cM), Fn1 (36.1 cM), Pecr, Igfbp2 (36.1 cM), Plcd4 (39.2 cM), Scg2 (43.6 cM), Irs1, and Inpp5d (57 cM) were identified. For QTL Nidd6 (77 cM), potential candidate gene Qscn6 was identified. For QTL Obq9 (88.4 cM), potential candidate genes Fmo1, Fmo3, and Apoa2 (92.6 cM) were identified. For QTL Wt6q2 (108 cM), potential candidate gene Hsd11b1 was identified.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:55285

TSOD male mice exhibit both obesity and diabetes enabling that strain to be used in a cross with BALB/cAJcl to elucidate the genetic basis for the phenotype. (BALB/cAJcl x TSOD)F1s and (TSOD x BALB/cAJcl)F1s were intercrossed to provide F2 populations for genotyping using SSLP markers.

A major gene on mouse Chromosome 1 effecting body weight (marker Nidd6) was significantly associated with a region close to markers D1Mit102 and D1Mit33 with a LOD score of 4.65.

References

• Original: J:55285 Hirayama I, et al., Genetic analysis of obese diabetes in the TSOD mouse. Diabetes. 1999 May;48(5):1183-91
• All: 1 reference(s)