Skts8^NIH/Ola
QTL Variant Detail

Summary

• QTL variant: Skts8^NIH/Ola
• Name: skin tumor susceptibility 8; NIH/Ola
• MGI ID: MGI:2154322
• QTL: Skts8 Location: Chr1:152794822-152795012 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 65.12 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NIH/Ola

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to skin tumorigenesis compared to M. spretus. (J:59049)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:59049

Susceptibility to skin papillomas in mice was analyzed in a backcross panel of 326 mice derived from (NIH/Ola female x M. spretus male)F1 female mice mated back to NIH/Ola male mice. Using negative binomial regression analysis, significant linkage of Skts8 with D1Mit47 (lod 3.17) was observed on mouse Chromosome 1.

References

• Original: J:59049 Nagase H, et al., A subset of skin tumor modifier loci determines survival time of tumor-bearing mice. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15032-7
• All: 1 reference(s)