Sox8^tm1Weg
Targeted Allele Detail

Summary

• Symbol: Sox8^tm1Weg
• Name: SRY (sex determining region Y)-box 8; targeted mutation 1, Michael Wegner
• MGI ID: MGI:2154329
• Synonyms: Sox8^lacZ
• Gene: Sox8 Location: Chr17:25784865-25789666 bp, - strand Genetic Position: Chr17, 12.69 cM
• Alliance: Sox8^tm1Weg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71578
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: In-frame insertion of a LacZ-neomycin resistance cassette replaced the complete open reading frame and both introns of the gene. RT-PCR and in situ hybridization studies indicate that expression of the LacZ marker replaced endogenous gene expression in homozygous mutant embryos and adult male mice. (J:71578)

Expression

In Mice Carrying this Mutation:	284 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox8 Mutation: 28 strains or lines available

References

• Original: J:71578 Sock E, et al., Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor sox8. Mol Cell Biol. 2001 Oct;21(20):6951-9
• All: 24 reference(s)