Stia1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Stia1^C57BL/6J
• Name: serum transfer induced arthritis 1; C57BL/6J
• MGI ID: MGI:2154342
• QTL: Stia1 Location: Chr1:158233173-158233272 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 68.38 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:70882

132 animals from a (C57BL/6J x NOD/LtDOI)F2 intercross were typed for 162 microsatellite markers at an average spacing of 7.84 cM to identify QTLs associated with susceptibility to rheumatoid arthritis. (C57BL/6J x NOD/LtDOI)F2 animals were inoculated with serum from K/BXN T cell receptor transgenic mice to induce arthritis. Parental strain C57BL/6J is susceptible to serum transfer induced arthritis whereas NOD/LtDOI is resistant. Stia1 (serum transfer induced arthritis 1) maps to 81.6 cM on mouse Chromosome 1 with a LOD score of 4.5 at D1Mit33. The Stia1 interval spans 79 cM - 92. cM. Stia2 maps to 23.5 cM on mouse Chromosome 2 with a LOD score of 7 at the Hc (hemolytic complement) locus. The Stia2 locus spans 11 cM - 41.4 cM. Hc is a possible candidategene for Stia2 because Hc appears to be required to develop arthritis via serum transfer, and Hc is known to be defective in the NOD/LtDOI strain.

References

• Original: J:70882 Ji H, et al., Genetic influences on the end-stage effector phase of arthritis. J Exp Med. 2001 Aug 6;194(3):321-30
• All: 1 reference(s)