Tlln^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Tlln^DBA/2J
• Name: tail length; DBA/2J
• MGI ID: MGI:2154361
• QTL: Tlln Location: Chr1:155837814-159390372 bp Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

This QTL exhibits additive inheritance and is also linked to mandible size phenotypes.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53812

Genome scan was performed on animals from a (C57BL/6J x DBA/2J)F2 intercross to identify QTLs associated with tail length and age-related body weight, and test concordance with QTLs mapped in a previous study. DBA/2J animals are heavier than C57BL/6J animals. Five out of 11 previously mapped QTLs were detected. QTLs for body weight at 3 weeks of age mapped to mouse chromosome 4 from 40 cM-60 cM (Bwtq2, LOD=4.4 at 55 cM), mouse chromosome 9 from 0 cM-50 cM (Bwtq4, LOD=8.3 at 8 cM), and mouse chromosome 11from 20 cM-55 cM (Bwtq5, LOD=9.5 at 27.8 cM). QTLs for body weight at 10 weeks of age mapped to mouse chromosome 1 from 40 cM-70 cM (Bwtq1, LOD=8.8 at 54.3 cM), mouse chromosome 6 from 0 cM-29 cM (Bwtq3, LOD=4.4 at 4 cM), and mouse chromosome 15 from 25 cM-50 cM (Bwtq6, LOD=7.6 at 41.2 cM). A major QTL for tail length mapped to mouse chromosome 1 from 40 cM-70 cM (Tlln, LOD=33 at 50 cM).

J:82262

Tlln was reported in a previous study and was confirmed and further characterized by additional genotyping of the original (C57BL/6J x DBA/2J)F2 population as well as a partial congenic strain and new F2 cross. Tlln was localized to an 8 cM interval between D1Mit30 and D1Mit57. C57BL/6J-derived alleles confer increased tail length at this locus and is inherited in an additive fashion. Tlln is linked to tail length at the 6- and 10-week time points. Tlln also appears to affect skeletal dimensions such as the length of the humerus, femur, tibia, mandible, scapula, and pelvic girdle.

References

• Original: J:53812 Morris KH, et al., Quantitative trait loci for growth traits in C57BL/6J x DBA/2J mice. Mamm Genome. 1999 Mar;10(3):225-8
• All: 4 reference(s)