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Wt10q1MH
QTL Variant Detail
Summary
QTL variant: Wt10q1MH
Name: body weight, 10 weeks, QTL 1; MH
MGI ID: MGI:2154366
QTL: Wt10q1  Location: unknown  Genetic Position: Chr1, Syntenic
Variant
origin
Strain of Specimen:  MH line
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers decreased body weight at 10 weeks compared to C57BL/6J. (J:55483)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Candidate Genes

J:91835

The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/Avy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/Avy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.

On mouse Chromosome 1, Idh1 (29.8 cM) showed differential expression between restricted and unrestricted diets on the A/a background. Diabesity QTLs mapping near Idh1 are Dbsty1 (21 cM),Insq2 (36 cM), Wt10q1 (25 cM), Wt6q1 (27 cM), Obq7 (28.7 cM), and Bw5 (36 cM). At another locus, Pea15 (93.8 cM) showed differential expression between restricted and unrestricted diets on the A/a background and F11r (93.3 cM) showed differential expression between A/a and A/Avy animals on the restricted diet. Diabesity QTL Obq9 (88.4 cM) maps near Pea15 and F11r.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:55483

Authors used a composite base population from four outbred strains (NIH, ICR, CF-1 and CFW) to select for lines showing a difference in heat loss. After 15 generations of selection, the MH line showed higher heat loss, consumed more feed, were leaner and more active than the ML line of mice. C57BL/6J was chosen as the inbred line to create a resource population from a cross between a selection line and an inbred line. Average heat loss and feed intake of the C57BL/6J mice were similar to that of mice from the ML line but their body composition was similar to the MH line. To identify QTLs that are responsible for heat loss and other phenotypes related to energy balance, a complete genome wide scan was conducted in a (MH x C57BL/6J)F2 intercross (n = 560). Regions harboring QTL with the greatest effects were then evaluated in a (MH x ML)F2 intercross (n = 560). A QTL influencing body weight at 10 weeks, Wt10q1 (LOD = 4.27, 3.3% of residual variance explained) was identified with a peak at 25 cM on Chromosome 1 in the (MH x C57BL/6J)F2 intercross. The MH allele was responsible for decreased body weight at 10 weeks for this QTL.

References
Original:  J:55483 Moody DE, et al., Identification of quantitative trait loci influencing traits related to energy balance in selection and inbred lines of mice. Genetics. 1999 Jun;152(2):699-711
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory