Bcr^tm1Hkp
Targeted Allele Detail

Summary

• Symbol: Bcr^tm1Hkp
• Name: BCR activator of RhoGEF and GTPase; targeted mutation 1, Nora Heisterkamp
• MGI ID: MGI:2154396
• Gene: Bcr Location: Chr10:74896424-75020753 bp, + strand Genetic Position: Chr10, 38.49 cM
• Alliance: Bcr^tm1Hkp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23804
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was partially replaced by insertion of a neomycin resistance expression cassette. Northern blot analysis with an exon 1 specific probe demonstrated that the transcript was not expressed in brain of homozygous mice, and western blot analysis on brain extracts showed that no protein was produced in homozygotes. (J:23804, J:199684)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bcr Mutation: 51 strains or lines available

References

• Original: J:23804 Voncken JW, et al., Increased neutrophil respiratory burst in bcr-null mutants. Cell. 1995 Mar 10;80(5):719-28
• All: 18 reference(s)