Cacna1a^rkr
Chemically induced Allele Detail

Summary

• Symbol: Cacna1a^rkr
• Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; rocker
• MGI ID: MGI:2154404
• Synonyms: rkr
• Gene: Cacna1a Location: Chr8:85065268-85366875 bp, + strand Genetic Position: Chr8, 40.95 cM
• Alliance: Cacna1a^rkr page

Mutation origin

• Strain of Origin: mixed

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A C to A transversion mutation at position 4073 (c.C>A4073) predicts a nonconservative threonine to lysine substitution at position 1358 (p.T1358K) in the extracellular pore-forming loop region that connects segments 5 and 6 of repeat III of the encoded protein. (J:71860)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cacna1a Mutation: 118 strains or lines available

References

• Original: J:71860 Zwingman TA, et al., Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a. J Neurosci. 2001 Feb 15;21(4):1169-78
• All: 3 reference(s)