Sluc5^O20/A
QTL Variant Detail

Summary

• QTL variant: Sluc5^O20/A
• Name: susceptibility to lung cancer 5; O20/A
• MGI ID: MGI:2154406
• QTL: Sluc5 Location: Chr1:168186243-168186402 bp Genetic Position: Chr1, cM position of peak correlated region/allele: 76.25 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: O20/A

Variant description

• Allele Type: QTL
• Inheritance: Other (see notes)

Notes

Sluc5 participates in additive interactions with other Sluc loci.

Animals homozygous for O20/A-derived alleles at Sluc5 and Sluc16 exhibit increased lung tumor size.

Animals homozygous for O20/A-derived alleles at Sluc5 and Sluc24 exhibit decreased lung tumor size.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50525

The fact that inbred O/20 was more susceptible to lung tumors then Congenic B10.O20 allowed for the mapping of lung tumor genes in OcB Recombinated Congenic strains. Lung tumor size and number could also be assesed by the QTL analysis of F2 mice derived from progenitor O/20 and various OcB strains. Analysis of F2 mice between O/20 and OcB-6 indicated a lung cancer susceptibility gene Sluc5 associated with mouse Chromosome 1 marker D1Mit15.

References

• Original: J:50525 Fijneman RJ, et al., High frequency of interactions between lung cancer susceptibility genes in the mouse: mapping of Sluc5 to Sluc14. Cancer Res. 1998 Nov 1;58(21):4794-8
• All: 2 reference(s)