Mol2^DBA/2N
QTL Variant Detail

Summary

• QTL variant: Mol2^DBA/2N
• Name: modifier of LPS-response 2; DBA/2N
• MGI ID: MGI:2154431
• QTL: Mol2 Location: Chr1:71624679-78183144 bp Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: DBA/2N

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased LPS response compared to BALB/cAnFcr. (J:58921)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:58921

The difference in the response to LPS (lipopolysaccharide) exhibited between C57BL/6J and A/J mice allowed for the mapping of QTls in AXB/BXA Recombinant Inbred strains. Four provisional modifers of the LPS response were mapped to mouse Chromosomes 1, 7, 11,and 13. Mol2 was localized to a 10.9 cM region flanked by markers Fn1 and D1Mit215. Moreover congenic strain C.D2-VIL6 expresed the MOl2 phenotype within a donor region that included markers D1Mit380 and D1Mit215.

References

• Original: J:58921 Matesic LE, et al., Mapping lipopolysaccharide response loci in mice using recombinant inbred and congenic strains. Genomics. 1999 Nov 15;62(1):34-41
• All: 1 reference(s)