Cycs^tm1Wlm
Targeted Allele Detail

Summary

• Symbol: Cycs^tm1Wlm
• Name: cytochrome c, somatic; targeted mutation 1, Robert Sanders Williams
• MGI ID: MGI:2154447
• Synonyms: Cyt c-
• Gene: Cycs Location: Chr6:50539543-50543518 bp, - strand Genetic Position: Chr6, 24.32 cM
• Alliance: Cycs^tm1Wlm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62276
• Parent Cell Line: KG-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the two protein coding exons. Immunoblot analysis did not detect endogenous protein in cells cultured from E8-E9 embryos of homozygous mutant mice. (J:62276)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cycs Mutation: 9 strains or lines available

References

• Original: J:62276 Li K, et al., Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Cell. 2000 May 12;101(4):389-99
• All: 5 reference(s)