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Sle1aC57BL/6J
QTL Variant Detail
Summary
QTL variant: Sle1aC57BL/6J
Name: systematic lupus erythematosus susceptibility 1a; C57BL/6J
MGI ID: MGI:2154450
QTL: Sle1a  Location: Chr1:168186243-170067328 bp  Genetic Position: Chr1, cM position of peak correlated region/allele: 74.86 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:67544

Systemic lupus erythematosus (Sle) is measured via anti-chromatin IgG production. Fine mapping of loci around Sle1 indicate that Sle1 actually corresponds to a cluster of loci related in part to Sle1. Various mating paradigms were used to dissect the Sle1 interval, including 493 (NZM2410 X C57BL/6J) F1 meioses. In addition (B6.Sle1 X C57BL/6J) x C57BL/6J recombinants were intercrossed to create more recombinants and to develop sublines on a C57BL/6J background.

Interestingly three non overlapping regions were identified within Sle1 designated as Sle1a, Sle1b and Sle1c. The following congenic intervals were identified.

Sle1a is included in an interval bounded by D1Mit15 and D1Mit353.

Sle1b is included in an interval bounded by D1Mit113 and D1Mit407 and by D1Mit113 and D1Mit206.

Sle1c is included in an interval bounded by D1Mit274 and D1Mit17.

References
Original:  J:67544 Morel L, et al., The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1787-92
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory