Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:67544Systemic lupus erythematosus (Sle) is measured via anti-chromatin IgG production. Fine mapping of loci around Sle1 indicate that Sle1 actually corresponds to a cluster of loci related in part to Sle1. Various mating paradigms were used to dissect the Sle1 interval, including 493 (NZM2410 X C57BL/6J) F1 meioses. In addition (B6.Sle1 X C57BL/6J) x C57BL/6J recombinants were intercrossed to create more recombinants and to develop sublines on a C57BL/6J background. Interestingly three non overlapping regions were identified within Sle1 designated as Sle1a, Sle1b and Sle1c. The following congenic intervals were identified. Sle1a is included in an interval bounded by D1Mit15 and D1Mit353. Sle1b is included in an interval bounded by D1Mit113 and D1Mit407 and by D1Mit113 and D1Mit206. Sle1c is included in an interval bounded by D1Mit274 and D1Mit17. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/22/2024 MGI 6.24 |
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