Sle1b^NZM2410/J
QTL Variant Detail

Summary

• QTL variant: Sle1b^NZM2410/J
• Name: systematic lupus erythematosus susceptibility 1b; NZM2410/J
• MGI ID: MGI:2154451
• Synonyms: Sle1b^z
• QTL: Sle1b Location: unknown Genetic Position: Chr1, cM position of peak correlated region/allele: 75.1 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZM2410/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased anti-chromatin antibody production compared to C57BL/6J. The following strains all carry this variant: NZM, 129X1/SvJ, A/J, AKR/J, BALB/cJ, C3H/HeJ, CBA/J, CE/J, DBA/2J, DDY/JcL, LP/J, MRL/MpJ, NOD/Lt, NZB/B1WJ, NZW, P/J, PL/J, SB/Le, SEA/GnJ, SJL/J, SM/J, WB/Re, PERA/EiJ, PERA/RkJ, PERC/EiJ, SK/CamEiJ, SF/CamEiJ (J:67544, J:94686)
• Inheritance: Dominant

Notes

Candidate Genes

J:94686

Congenic and physical mapping was used to show that Sle1b mapped within an interval containing SLAM family members ordered as Cd244 - Ly9 - Slamf7 - Cd48 - Slamf1 - Cd84 - Slamf6. Haplotype analysis of the aformentioned region were suggestive that the markers contained within the region as contributing to the Sle1b phenotype. The strongest contribution may come from Slamf6.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:67544

Systemic lupus erythematosus (Sle) is measured via anti-chromatin IgG production. Fine mapping of loci around Sle1 indicate that Sle1 actually corresponds to a cluster of loci related in part to Sle1. Various mating paradigms were used to dissect the Sle1 interval, including 493 (NZM2410 X C57BL/6J) F1 meioses. In addition (B6.Sle1 X C57BL/6J) x C57BL/6J recombinants were intercrossed to create more recombinants and to develop sublines on a C57BL/6J background.

Interestingly three non overlapping regions were identified within Sle1 designated as Sle1a, Sle1b and Sle1c. The following congenic intervals were identified.

Sle1a is included in an interval bounded by D1Mit15 and D1Mit353.

Sle1b is included in an interval bounded by D1Mit113 and D1Mit407 and by D1Mit113 and D1Mit206.

Sle1c is included in an interval bounded by D1Mit274 and D1Mit17.

References

• Original: J:67544 Morel L, et al., The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1787-92
• All: 10 reference(s)