Pex5^tm1Baes
Targeted Allele Detail

Summary

• Symbol: Pex5^tm1Baes
• Name: peroxisomal biogenesis factor 5; targeted mutation 1, Myriam Baes
• MGI ID: MGI:2154454
• Synonyms: Pex5-
• Gene: Pex5 Location: Chr6:124373775-124392026 bp, - strand Genetic Position: Chr6, 59.15 cM
• Alliance: Pex5^tm1Baes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42719
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Four exons encoding most of the tetratricopeptide repeats were replaced by a neo cassette. The absence of transcript was confirmed by Northern analysis and RT-PCR. By Western analysis, neither the 70kDa protein nor truncated forms were detectable from liver extracts. (J:42719)

Expression

In Mice Carrying this Mutation:	29 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pex5 Mutation: 30 strains or lines available

References

• Original: J:42719 Baes M, et al., A mouse model for Zellweger syndrome. Nat Genet. 1997 Sep;17(1):49-57
• All: 11 reference(s)