Cdx1^tm1Pgr
Targeted Allele Detail

Summary

• Symbol: Cdx1^tm1Pgr
• Name: caudal type homeobox 1; targeted mutation 1, Peter Gruss
• MGI ID: MGI:2154514
• Synonyms: Cdx1-
• Gene: Cdx1 Location: Chr18:61151934-61169271 bp, - strand Genetic Position: Chr18, 34.41 cM
• Alliance: Cdx1^tm1Pgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29755
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a TK-neomycin resistance cassette in reverse transcriptional orientation into exon 3 introduced a premature stop codon upstream of sequences that code for the carboxy terminus, which includes the recognition helix. Western blot analysis using antibodies raised to the amino terminus of the protein did not detect protein in intestine of homozygous mutant mice. (J:29755)

Expression

In Mice Carrying this Mutation:	63 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdx1^tm1Pgr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdx1 Mutation: 13 strains or lines available

References

• Original: J:29755 Subramanian V, et al., Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell. 1995 Nov 17;83(4):641-53
• All: 31 reference(s)