Pth1r^tm1Hmk
Targeted Allele Detail

Summary

• Symbol: Pth1r^tm1Hmk
• Name: parathyroid hormone 1 receptor; targeted mutation 1, Henry M Kronenberg
• MGI ID: MGI:2154519
• Synonyms: PTHrP receptor-
• Gene: Pth1r Location: Chr9:110551153-110576213 bp, - strand Genetic Position: Chr9, 60.56 cM, cytoband F
• Alliance: Pth1r^tm1Hmk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34604
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons E2 through T, which encode most of the receptor. In situ hybridization using a probe transcribed from rat receptor cDNA detected strong signal in four, and no signal in one, of five E9.5 embryos from heterozygous matings. (J:34604)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pth1r Mutation: 29 strains or lines available

References

• Original: J:34604 Lanske B, et al., PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth [see comments]. Science. 1996 Aug 2;273(5275):663-6
• All: 21 reference(s)