Cdk4^tm1.1Bbd
Targeted Allele Detail

Summary

• Symbol: Cdk4^tm1.1Bbd
• Name: cyclin dependent kinase 4; targeted mutation 1.1, Mariano Barbacid
• MGI ID: MGI:2154521
• Synonyms: Cdk4^R, Cdk4 R24C, Cdk4^R24C
• Gene: Cdk4 Location: Chr10:126899404-126903157 bp, + strand Genetic Position: Chr10, 74.5 cM, cytoband D3
• Alliance: Cdk4^tm1.1Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54534
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: This allele is a derivative of Cdk4^tm1Bbd in which the neomycin resistance cassette was deleted via Cre-mediated recombination in the germ line. These mice express comparable levels of mutant protein to wild-type levels. (J:54534)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdk4^tm1.1Bbd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk4 Mutation: 58 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Melanoma (J:189221)

References

• Original: J:54534 Rane SG, et al., Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet. 1999 May;22(1):44-52
• All: 55 reference(s)