Feml1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Feml1^C57BL/6J
• Name: femur length in high growth mice 1; C57BL/6J
• MGI ID: MGI:2154532
• QTL: Feml1 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased femur length compared to CAST/EiJ. (J:68441)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Feml1 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68441

Authors indicated that enhanced growth rate in C57BL/6J-Cish2^hg/Cish2^hg mice may be modulated by other genes associated with growth. 1132 F2 mice from a cross between (C57BL/6J-Cish2^hg/Cish2^hg X CAST/EiJ)F1's yielded 274 +/+ , 596 hg/+ and 262 hg/hg mice withthe hg/hg used in a genome wide scan to find QTLs associated with growth rates. A total of 15 QTLs were mapped. QTLs for total weight gain (wg1 - wg4) mapped to mouse Chromosomes 2, 8, and 11, with wg1 and wg2 mapping to mouse chromosome 2. QTLS for total carcass protein (Carp1-Carp3) mapped to Chromosomes 2, 11 and 17. QTLs for total carcass ash weight (Cara1-Cara3) mapped to mouse Chromosomes 2, 11 and 17. QTLs for percent carcass fat (Carf1 and Carf2) mapped to mouse Chromosomes 5 and 9 and QTLS for femur length (Feml1-Feml3) mapped to mouse chromosomes 2, 9, and 17.

References

• Original: J:68441 Corva PM, et al., Quantitative trait loci affecting growth in high growth (hg) mice. Mamm Genome. 2001 Apr;12(4):284-90
• All: 1 reference(s)