App^tm2Cwe
Targeted Allele Detail

Summary

• Symbol: App^tm2Cwe
• Name: amyloid beta precursor protein; targeted mutation 2, Charles Weissmann
• MGI ID: MGI:2154535
• Synonyms: APP^_, beta APP 0
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^tm2Cwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36648
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Cre-mediated recombination resulted in the deletion of 200kb of the gene, from exon 2 - 17. (J:36648)

Expression

In Mice Carrying this Mutation:	6 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any App Mutation: 105 strains or lines available

References

• Original: J:36648 Li ZW, et al., Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells [published erratum appears in Proc Natl Acad Sci U S A 1996 Oct 15;93(21):12052]. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):6158-62
• All: 27 reference(s)