Cyp19a1^tm1Esi
Targeted Allele Detail

Summary

• Symbol: Cyp19a1^tm1Esi
• Name: cytochrome P450, family 19, subfamily a, polypeptide 1; targeted mutation 1, Evan R Simpson
• MGI ID: MGI:2154536
• Synonyms: ArKO
• Gene: Cyp19a1 Location: Chr9:54073221-54175394 bp, - strand Genetic Position: Chr9, 29.49 cM
• Alliance: Cyp19a1^tm1Esi page

Increased adipocyte size in Cyp19a1^tm1Esi/Cyp19a1^tm1Esi mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48086
• Parent Cell Line: KG-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a neomycin resistance cassette into exon 9 disrupted the gene. Aromatase activity was not detected in ovaries of 12 week old homozygous mutant mice. (J:48086)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	34 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyp19a1 Mutation: 39 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Metabolic Syndrome in mice homozygous for Apoe^tm1Unc and Cyp19a1^tm1Esi (J:184647)

References

• Original: J:48086 Fisher CR, et al., Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6965-70
• All: 61 reference(s)