Cav1^tm1Kur
Targeted Allele Detail

Summary

• Symbol: Cav1^tm1Kur
• Name: caveolin 1, caveolae protein; targeted mutation 1, Teymuras V Kurzchalia
• MGI ID: MGI:2154537
• Synonyms: Cav^-, cav-1-, Cav-1 KO
• Gene: Cav1 Location: Chr6:17306387-17341323 bp, + strand Genetic Position: Chr6, 7.73 cM, cytoband A2
• Alliance: Cav1^tm1Kur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71760
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 3, which encodes the transmembrane domain, the palmitoylation sites and the scaffolding domains. RT-PCR analysis revealed that no transcript was present in lung total RNA derived from homozygous mice, and western blot analysis demonstrated that no protein was detectable in lung and heart extracts from homozygous mice. (J:71760)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cav1 Mutation: 31 strains or lines available

References

• Original: J:71760 Drab M, et al., Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science. 2001 Sep 28;293(5539):2449-52
• All: 58 reference(s)