Itgb1^tm3Ref
Targeted Allele Detail

Summary

• Symbol: Itgb1^tm3Ref
• Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 3, Reinhard Fassler
• MGI ID: MGI:2154539
• Synonyms: beta1^geo
• Gene: Itgb1 Location: Chr8:129412135-129459681 bp, + strand Genetic Position: Chr8, 76.09 cM, cytoband E2
• Alliance: Itgb1^tm3Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28330
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A promoterless lacZ-neomycin resistance gene fusion was inserted in-frame to the ATG of the gene. A beta-galactosidase protein is expressed from this allele under the control of the Itgb1 promoter. (J:28330)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb1 Mutation: 60 strains or lines available

References

• Original: J:28330 Fassler R, et al., Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev. 1995 Aug 1;9(15):1896-908
• All: 3 reference(s)