Itgb1^tm1Lscd
Targeted Allele Detail

Summary

• Symbol: Itgb1^tm1Lscd
• Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 1, Caroline H Damsky
• MGI ID: MGI:2154540
• Synonyms: beta1-null, Itgbeta1^-
• Gene: Itgb1 Location: Chr8:129412135-129459681 bp, + strand Genetic Position: Chr8, 76.09 cM, cytoband E2
• Alliance: Itgb1^tm1Lscd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28266
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A promoterless neomycin resistance gene fusion was inserted in-frame into exon 2 of the gene. (J:28266)

Disease models

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itgb1 Mutation: 60 strains or lines available

References

• Original: J:28266 Stephens LE, et al., Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev. 1995 Aug 1;9(15):1883-95
• All: 12 reference(s)