Hmx2^tm1Tlu
Targeted Allele Detail

Summary

• Symbol: Hmx2^tm1Tlu
• Name: H6 homeobox 2; targeted mutation 1, Thomas Lufkin
• MGI ID: MGI:2154542
• Synonyms: Hmx2^lacZ-
• Gene: Hmx2 Location: Chr7:131150502-131159743 bp, + strand Genetic Position: Chr7, 74.34 cM
• Alliance: Hmx2^tm1Tlu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73069
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Insertion of an IRES-lacZ-neomycin resistance cassette into exon 2, which encodes the third helix of the homeodomain, introduced premature translation stop codons in all three open reading frames. This allele produces beta-galactosidase and neomycin phosphotransferase under the control of the endogenous promoter. The authors predict that this allele would also produce a truncated protein that lacks the carboxy terminus. RNase protection analysis did not detect wild-type homeobox in homozygous mutant embryos. (J:73069)

Expression

In Mice Carrying this Mutation:	62 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmx2 Mutation: 15 strains or lines available

References

• Original: J:73069 Wang W, et al., Hmx2 homeobox gene control of murine vestibular morphogenesis. Development. 2001 Dec;128(24):5017-29
• All: 1 reference(s)