Itgb1^tm2Son
Targeted Allele Detail

Summary

• Symbol: Itgb1^tm2Son
• Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 2, Arnoud Sonnenberg
• MGI ID: MGI:2154544
• Synonyms: beta1D ki
• Gene: Itgb1 Location: Chr8:129412135-129459681 bp, + strand Genetic Position: Chr8, 76.09 cM, cytoband E2
• Alliance: Itgb1^tm2Son page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47279
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6, encoding the beta1A isoform, was replaced by a cDNA fragment encoding beta1D. A neomycin resistance cassette also replaced exon D, encoding the sequences for the beta1D isoform. (J:47279)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb1 Mutation: 60 strains or lines available

References

• Original: J:47279 Baudoin C, et al., Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development. Genes Dev. 1998 Apr 15;12(8):1202-16
• All: 2 reference(s)