Fmod^tm1Aol
Targeted Allele Detail

Summary

• Symbol: Fmod^tm1Aol
• Name: fibromodulin; targeted mutation 1, Ake Oldberg
• MGI ID: MGI:2154550
• Synonyms: Fmod-
• Gene: Fmod Location: Chr1:133964992-133976015 bp, + strand Genetic Position: Chr1, 58.09 cM
• Alliance: Fmod^tm1Aol page

Abnormal tendon collagen fiber bundles in Fmod^tm1Aol/Fmod⁺ and Fmod^tm1Aol/Fmod^tm1Aol tails

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54069
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 2, at a position corresponding to amino acid 8 (tryptophan) in the mature protein. (J:54069)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fmod Mutation: 22 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Temporomandibular Joint Osteoarthritis J:112779, J:117908, J:226593 in mice homozygous or hemizygous for Bgn^tm1Mfy and homozygous for Fmod^tm1Aol.

References

• Original: J:54069 Svensson L, et al., Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon. J Biol Chem. 1999 Apr 2;274(14):9636-47
• All: 37 reference(s)