Lama3^tm1Crt
Targeted Allele Detail

Summary

• Symbol: Lama3^tm1Crt
• Name: laminin, alpha 3; targeted mutation 1, William G Carter
• MGI ID: MGI:2154553
• Synonyms: alpha3-
• Gene: Lama3 Location: Chr18:12466876-12716070 bp, + strand Genetic Position: Chr18, 6.2 cM, cytoband A
• Alliance: Lama3^tm1Crt page

Progressive blistering and reduced milk content in the stomach of Lama3^tm1Crt/Lama3^tm1Crt mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55865
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon A3. This exon encodes sequences common to both isoforms of the protein. Removal of this exon is predicted to cause a frameshift mutation and result in premature termination of the protein. Immunohistochemistry analysis on skin derived from homozygous mice confirmed that the protein was not detectable. (J:55865)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lama3 Mutation: 192 strains or lines available

References

• Original: J:55865 Ryan MC, et al., Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells. J Cell Biol. 1999 Jun 14;145(6):1309-23
• All: 2 reference(s)