Tnr^tm1Msch
Targeted Allele Detail

Summary

• Symbol: Tnr^tm1Msch
• Name: tenascin R; targeted mutation 1, Melitta Schachner
• MGI ID: MGI:2154583
• Synonyms: tn-r-
• Gene: Tnr Location: Chr1:159351339-159759299 bp, + strand Genetic Position: Chr1, 69.03 cM, cytoband E2
• Alliance: Tnr^tm1Msch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55338
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing the coding region of exon 1 and part of intron 1 was replaced by a neomycin resistance cassette. Nothern blot and RT-PCR analysis demonstrated that an aberrant transcript is produced from this allele in total brain RNA from homozygous mice, but western blot analysis confirmed the absence of the protein in extracts derived from brains of homozygous mice. (J:55338)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnr Mutation: 65 strains or lines available

References

• Original: J:55338 Weber P, et al., Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS. J Neurosci. 1999 Jun 1;19(11):4245-62
• All: 30 reference(s)