Sgcb^tm1Oza
Targeted Allele Detail

Summary

• Symbol: Sgcb^tm1Oza
• Name: sarcoglycan, beta (dystrophin-associated glycoprotein); targeted mutation 1, Eijiro Ozawa
• MGI ID: MGI:2154611
• Synonyms: BSG -
• Gene: Sgcb Location: Chr5:73790092-73805080 bp, - strand Genetic Position: Chr5, 38.89 cM
• Alliance: Sgcb^tm1Oza page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57590
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 2. Northern blot analysis demonstrated that the transcript was not detectable in total RNA derived from skeletal muscle of homozygous mice, and western blot analysis confirmed that the protein was not detectable in microsomal preparations of skeletal muscle of homozygous mice. (J:57590)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sgcb Mutation: 23 strains or lines available

References

• Original: J:57590 Araishi K, et al., Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophy in beta-sarcoglycan-deficient mice. Hum Mol Genet. 1999 Sep;8(9):1589-98
• All: 2 reference(s)