Col11a2^tm1Mne
Targeted Allele Detail

Summary

• Symbol: Col11a2^tm1Mne
• Name: collagen, type XI, alpha 2; targeted mutation 1, Richard Mayne
• MGI ID: MGI:2154689
• Gene: Col11a2 Location: Chr17:34258411-34285659 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Col11a2^tm1Mne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71948
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin-resistance cassette was inserted between restriction sites in exons 27 and 28. A short, aberrant trancript was produced from the targeted allele, which could be detected by Northern blotting. However, translation of the full-length protein is predicted to result in a truncated protein, due to the presence of termination codons. (J:71948)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col11a2 Mutation: 63 strains or lines available

References

• Original: J:71948 Li SW, et al., Targeted disruption of Col11a2 produces a mild cartilage phenotype in transgenic mice: Comparison with the human disorder otospondylomegaepiphyseal dysplasia (OSMED). Dev Dyn. 2001 Oct;222(2):141-52
• All: 4 reference(s)