Sgcg^tm1Mcn
Targeted Allele Detail

Summary

• Symbol: Sgcg^tm1Mcn
• Name: sarcoglycan, gamma (dystrophin-associated glycoprotein); targeted mutation 1, Elizabeth M McNally
• MGI ID: MGI:2154693
• Synonyms: gsg -
• Gene: Sgcg Location: Chr14:61456564-61495939 bp, - strand Genetic Position: Chr14, 32.27 cM, cytoband C3
• Alliance: Sgcg^tm1Mcn page

Stunted growth and abnormal stance in Sgcg^tm1Mcn/Sgcg^tm1Mcn mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49871
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exon 2, which encodes the initiation codon, the cytoplasmic tail and the transmembrane domain of the encoded protein. (J:49871)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sgcg Mutation: 19 strains or lines available

References

• Original: J:49871 Hack AA, et al., Gamma-sarcoglycan deficiency leads to muscle membrane defects and apoptosis independent of dystrophin. J Cell Biol. 1998 Sep 7;142(5):1279-87
• All: 28 reference(s)