Hdl1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Hdl1^C57BL/6J
• Name: high density lipoprotein (HDL) level 1; C57BL/6J
• MGI ID: MGI:2154922
• QTL: Hdl1 Location: Chr2:65269746-65269934 bp Genetic Position: Chr2, cM position of peak correlated region/allele: 38.54 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased HDL cholesterol on an atherogenic diet compared to CAST/Ei. (J:66421)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66421

A (CAST/Ei x C57BL/6J)F2 intercross was typed for polymorphic markers on all mouse chromosomes except the Y Chromosome at an average marker density of 10 cM to identify loci associated with plasma HDL levels in response to either chow or atherogenic diet. Inbred parental strain CAST/Ei exhibits lower plasma HDL levels compared to inbred parental strain C57BL/6J, with (CAST/Ei x C57BL/6J)F1 hybrids displaying an intermediate phenotype. HDL-associated QTLs with a LOD>4.3 threshold were detected and are as follows. Hdl1, a QTL associated with HDL levels on an atherogenic diet, mapped to mouse Chromosome 2 at approximately 37 cM with a peak LOD = 5.6 at D2Mit9. Hdl1 co-localizes with loci mapped for body fat and insulin levels. Pltp, a possible candidate gene for Hdl1, did not appear to segregate with this locus. Hdl2, a QTL associated with HLD levels on an atherogenic, diet mapped to mouse Chromosome 5 from 35 cM - 60 cM with a peak LOD = 6.1 near D5Mit10. Previously mapped HDL QTLs using different inbred strains are located near Hdl2. A possible candidate gene for Hdl2 is Srb1, but following investigation the authors conclude this QTL is unlikely due to the effect of Srb1. Hdl3, a QTL associate with HDL levels on a chow diet, mapped to mouse Chromosome 16 from 9.61 cM - 38.0 cM with a peak LOD = 4.4 near D16Mit3. The LOD score peaks over the gene for ApoD but no difference in ApoD expression is apparent between CAST/Ei and C57BL/6J. Hdl4, a QTL associated with HDL levels on an atherogenic diet, mapped to mouse Chromosome 17 from 20 cM - 48 cM with a peak LOD = 6.5 near D17Mit7. Suggestive QTLs associated with HDL levels with LOD>2.8 (but less than 4.3) mapped to Chromosome 2 near D2Mit50, Chromosome 3 near D3Mit12, Chromosome 8 near D8Mit12 and D8Mit14, Chromosome 9 near D9Mit2, Chromosome 14 near D14Mit2, Chromosome 18 near D18Mit142, and Chromosome 19 near D19Mit5.

References

• Original: J:66421 Mehrabian M, et al., Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei x C57BL/6J). J Lipid Res. 2000 Dec;41(12):1936-46
• All: 1 reference(s)