Fob1^{F line}
QTL Variant Detail

Summary

• QTL variant: Fob1^{F line}
• Name: F-line obesity QTL 1; F line
• MGI ID: MGI:2154958
• QTL: Fob1 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: F line

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased fat percentage compared to L line. (J:59227)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Fob1 exhibits an additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:59227

Mice were selected for 53 generations for high and low fat content. High (F line) and Low (L line) mice were crossed creating F1 offspring that were mated to produce 436 F2 mice (233 females and 213 males). The F2 mice were genotyped for 71 MIT markers polymorphic in the progenitor strains to identify QTLs that contributed to the fat content phenotype. Fob1 as a QTL showed a significant peak LOD score of 4.0 at an approximate cM position of 45 on mouse Chromosome 2. Fob1 accounted for approximately 4.9 percent of the total fat variance across the F2 population explained by the QTL.

References

• Original: J:59227 Horvat S, et al., Mapping of obesity QTLs in a cross between mouse lines divergently selected on fat content. Mamm Genome. 2000 Jan;11(1):2-7
• All: 1 reference(s)