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Insq7C57BL/6
QTL Variant Detail
Summary
QTL variant: Insq7C57BL/6
Name: insulin QTL 7; C57BL/6
MGI ID: MGI:2154965
QTL: Insq7  Location: Chr2:26384446-26384575 bp  Genetic Position: Chr2, cM position of peak correlated region/allele: 18.92 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers susceptibility to hyperinsulinemia compared to 129/SvIr. (J:61489)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:61489

A genome scan with an average marker resolution of 20 cM was conducted on 6 month old male mice from a (C57BL/6 x 129SvIR)F2 intercross to map QTLs affecting susceptibility to hyperinsulinemia. Female mice of either strain do not develop hyperinsulinemia and were excluded from the study. The 129SvIR strain carries a mutation in the insulin receptor gene on Chromosome 8 and develops extreme hyperinsulinemia (elevated blood insulin). C57BL/6 does not develop hyperinsulinemia with or without mutation to the insulin receptor gene. The authors mapped 2 major QTLs involved in modulating blood insulin levels: Insq7 on chromosome 2 spanning 27.6 cM - 42.9 cM (LOD = 5.58 at D2Mit151) and Insq9 on chromosome 10 spanning 29 cM - 69 cM (LOD = 5.58 at D10Mit42). Also mapped were 3 suggestive QTLs: Insq6 on Chromosome 1 spanning 38.3 cM - 59.7 cM (LOD = 3.58 at D1Mit19), Insq8 on Chromosome 6 at 56.6 cM (LOD = 2.79 at D6Mit201), and Insq10 on Chromosome 12 at 44.1 cM (LOD = 3.11 at D12Mit231). Insq7 on Chromosome 2 and Insq9 on Chromosome 10 span a broad region and may contain multiple genes modulating plasma insulin Chromosome

References
Original:  J:61489 Kido Y, et al., Genetic modifiers of the insulin resistance phenotype in mice. Diabetes. 2000 Apr;49(4):589-96
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory