Gvhd3^C57BL/10Sn
QTL Variant Detail

Summary

• QTL variant: Gvhd3^C57BL/10Sn
• Name: graft-versus host disease 3; C57BL/10Sn
• MGI ID: MGI:2154975
• QTL: Gvhd3 Location: Chr2:117942930-117943090 bp Genetic Position: Chr2, cM position of peak correlated region/allele: 59.34 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/10Sn

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased weight loss compared to DBA/2J. (J:55766)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:55766

A genome wide scan for markers that influence graft-versus-host disease was undertaken in (B10.D2 x DBA/2) X DBA/2 and (B10.D2 x DBA/2) X B10.D2 mice. The phenotype was determined by weight loss or death within 30 days of bone marrow transplantation. In 85 (B10.D2 x DBA/2) X B10.D2 a highly significant association of the weight loss phenotype with mouse Chromosome 2 marker D2Mit62 was observed, suggestive of a major QTL(Gvhd3) in this region.

References

• Original: J:55766 Harper JM, et al., A locus on chromosome 2 influences the development of acute graft-versus-host disease in a murine model. Bone Marrow Transplant. 1999 Jun;23(11):1183-90
• All: 1 reference(s)