Dssc2^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Dssc2^C3H/HeJ
• Name: dextran sodium sulfate induced colitis QTL2; C3H/HeJ
• MGI ID: MGI:2155047
• QTL: Dssc2 Location: Chr2:24224632-148700377 bp Genetic Position: Chr2, cM position of peak correlated region/allele: 47.93 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased colitis susceptibility compared to C57BL/6J. (J:52852)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Dssc2 exhibits an additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52852

The genetic basis for differential sensitivity of inbred mice to inflammatory bowel disease induced by dextran sulfate sodium (DSS) was investigated by crossing susceptible C3H/HeJ mice to partially resistant C57BL/6J mice. 86 (C3H/HeJ x C57BL/6J)F2 miceand 90 [(C3H/HeJ x C57BL/6J) x C57BL/6J]N2 backcross mice were analyzed for the presence of QTLs influencing DSS-induced colitis. An additive QTL on mouse Chromosome 2 between D2Mit292 and D2Mit282 (susceptibility marked by the C3H allele at D2Mit94) was significantly linked to several of the colon subphenotypes like severity, hyperplasia, ulceration, and % area involved. The confidence level for linkage of QTL to markers on Chromosome 2 exceeded the threshold for declaring significant linkage (P = 0.0000178). Possible candidate genes in the region include Itga4, Il1a and Il1b. Reduced DSS-induced susceptibility was also observed in congenic stocks in which the highly susceptible NOD/Lt strain carried putative resistance alleles from C57BL/6J on mouse Chromosome 2 confirming the presence of a susceptibility QTL in this region.

References

• Original: J:52852 Mahler M, et al., Genetic analysis of susceptibility to dextran sulfate sodium-induced colitis in mice. Genomics. 1999 Jan 15;55(2):147-56
• All: 1 reference(s)