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Dssc2C57BL/6J
QTL Variant Detail
Summary
QTL variant: Dssc2C57BL/6J
Name: dextran sodium sulfate induced colitis QTL2; C57BL/6J
MGI ID: MGI:2155048
QTL: Dssc2  Location: Chr2:24224632-148700377 bp  Genetic Position: Chr2, cM position of peak correlated region/allele: 47.93 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers decreased colitis susceptibility compared to C3H/HeJ.
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52852

The genetic basis for differential sensitivity of inbred mice to inflammatory bowel disease induced by dextran sulfate sodium (DSS) was investigated by crossing susceptible C3H/HeJ mice to partially resistant C57BL/6J mice. 86 (C3H/HeJ x C57BL/6J)F2 miceand 90 [(C3H/HeJ x C57BL/6J) x C57BL/6J]N2 backcross mice were analyzed for the presence of QTLs influencing DSS-induced colitis. An additive QTL on mouse Chromosome 2 between D2Mit292 and D2Mit282 (susceptibility marked by the C3H allele at D2Mit94) was significantly linked to several of the colon subphenotypes like severity, hyperplasia, ulceration, and % area involved. The confidence level for linkage of QTL to markers on Chromosome 2 exceeded the threshold for declaring significant linkage (P = 0.0000178). Possible candidate genes in the region include Itga4, Il1a and Il1b. Reduced DSS-induced susceptibility was also observed in congenic stocks in which the highly susceptible NOD/Lt strain carried putative resistance alleles from C57BL/6J on mouse Chromosome 2 confirming the presence of a susceptibility QTL in this region.

References
Original:  J:52852 Mahler M, et al., Genetic analysis of susceptibility to dextran sulfate sodium-induced colitis in mice. Genomics. 1999 Jan 15;55(2):147-56
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory