Etohr^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Etohr^C57BL/6J
• Name: ethanol response acute; C57BL/6J
• MGI ID: MGI:2155093
• QTL: Etohr Location: Chr2:80005954-80006113 bp Genetic Position: Chr2, cM position of peak correlated region/allele: 47.93 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers decreased locomotor activity in response to alcohol challenge compared to DBA/2J. (J:52042)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52042

Changes in locomotor activity due to ethanol was analysed in BXD RI stains and in 900 F2 (C57BL/6J x DBA/2J) intercross mice. The RI data provided a suggestive association of the locomotor response with markers on various chromosomes including mouse Chromosome 2. The mouse Chromosome 2 location was verified in the F2 cross and reached a level of significance when combined with the RI data. The activity QTL (Etohr) on mouse chromosome 2 had a peak LOD of 5.3 with an approximate cM position of 48 and was associated with markers D2Mit94 and D2Mit420.

References

• Original: J:52042 Demarest K, et al., Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2. J Neurosci. 1999 Jan 15;19(2):549-61
• All: 1 reference(s)