Cons1^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Cons1^DBA/2J
• Name: consumption-saccharin intake 1; DBA/2J
• MGI ID: MGI:2155102
• QTL: Cons1 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50271

841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Etohcta2 (P<0.01) mapped to a region of Chromosome 2 spanning 19.5 cM - 30.0 cM in linkage with Rmp2 (23.5 cM) and Rmp3 (19.5 cM). *Editor's Note: current position of Rmp3 on MGI is mouse chromosome 17, 19.5 cM* Etohcta2 is associated with ethanol-induced taste aversion at high-dose ethanol injection following the paired taste. A QTL involved in ethanol-related acute withdrawal appears to overlap Etohcta2. Taste1 (P<0.01 at D2Mit379) and Taste2 (P<0.01 at Epb4.2) mapped to 38.3 cM and 67 cM on Chromosome 2, respectively, and are associated with saccharin preference. Cons1 (P<0.01) is linked to D2Ncvs43 on Chromosome 2 at an unknown location and is associated with preconditioned saccharin intake.

References

• Original: J:50271 Risinger FO, et al., Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res. 1998 Sep;22(6):1234-44
• All: 1 reference(s)