Tlq1^BALB/c
QTL Variant Detail

Summary

• QTL variant: Tlq1^BALB/c
• Name: telomere length QTL 1; BALB/c
• MGI ID: MGI:2155124
• QTL: Tlq1 Location: unknown Genetic Position: Chr2, cM position of peak correlated region/allele: 100.95 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BALB/c

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased telomere length compared to M. spretus. (J:48933)
• Inheritance: Dominant

Notes

Candidate Genes

J:91351

Rtel1 is a candidate gene for a previously mapped telomere length QTL named Tlq1 positioned at the distal end of mouse Chromosome 2. Rtel1/Tlq1 is located approximately 2 cM from the telomere at around 107 cM. An Rtel1 EST and cDNAs from Stmn3 and Arfrp1 hybrizided to BAC clone RP23-60M5. The order of genes at this locus is as follows:

centromere - Stmn3 - Rtel1 - Arfrp1 - telomere

References

• Original: J:48933 Zhu L, et al., Telomere length regulation in mice is linked to a novel chromosome locus. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8648-53
• All: 1 reference(s)