Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:49054Authors isolated quantitative trait loci believed to be invloved with the disease frequency of experimental allergic encephalomyelitis (EAE). (SJL/J x B10.S/DvTe)F2; SJL/J (susceptible) and B10.S/DvTe (resistant) mice; were bred to create F2 progeny used in the analysis. A genome wide scan of 291 affected and 390 unaffected animals indicated the presence of a locus mapping to mouse Chromosome 2, named Eae8 by the authors.J:34892In order to localize quantitative trait loci (QTLs) affecting the experimental autoimmune encephalomyelitis (EAE) phenotype, 68 susceptible and 68 immune mice derived from a (B10.S x SJL/J)F1 x B10.S backcross were analyzed. The SJL/J strain is highly susceptible to EAE while B10.S is resistant. QTL Eae8 (p = 0.001) was localized on mouse Chromosome 2 in an interval containing D2Mit147, D2Mit148 and D2Mit213. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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