Obq3^AKR/J
QTL Variant Detail

Summary

• QTL variant: Obq3^AKR/J
• Name: obesity QTL 3; AKR/J
• MGI ID: MGI:2155173
• QTL: Obq3 Location: unknown Genetic Position: Chr2, cM position of peak correlated region/allele: 50.66 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: AKR/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased adiposity in male animals compared to C57L/J. (J:39947)
• Inheritance: Other (see notes)

Notes

Obq3 exhibits an additive mode of inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:39947

Statistical analysis of 93 individual genotypes (up to 339 for select markers) from (AKR/J x C57L/J)F2 fat and lean pool mice indicated the presence of a QTL locus on mouse Chromosome 2 affecting the adiposity index. A LOD peak score of 5.1 occurred at aposition 2 cM distal to D2Mit15. A broad 1-LOD support interval extending from ~6 cM distal to D2Mit237 to ~3.0 cM proximal to D2Mit168 was found to be consistant with either a one or two gene model. Gene order and percentage of recombination between markers is reported as: D2Mit296 - 2.8 - D2Mit237 - 20.4 - D2Mit66 - 0.8 - D2Mit15 - 9.1 - D2Mit62 - 10.7 - D2Mit168 - 20.3 - D2Mit311. This QTL is reported to account for 7.0% of the phenotype variance.

References

• Original: J:39947 Taylor BA, et al., Obesity QTLs on mouse chromosomes 2 and 17. Genomics. 1997 Aug 1;43(3):249-57
• All: 1 reference(s)