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Bfq1C57BL/10SnJ
QTL Variant Detail
Summary
QTL variant: Bfq1C57BL/10SnJ
Name: body fat QTL 1; C57BL/10SnJ
MGI ID: MGI:2155178
QTL: Bfq1  Location: unknown  Genetic Position: Chr2, Syntenic
Variant
origin
Strain of Specimen:  C57BL/10SnJ
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:42700

A total of 84 female (NZB/BlNJ x SM/J)F2 mice were analyzed for 126 genetic markers covering all mouse chromosomes except for the Y Chromosome. An obesity quantitative trait locus (QTL) Bfq1, was significantly associated with a region of mouse Chromosome2 bounded distally by D2Mit28 and proximally by D2Mit22. Additionally, mouse congenic strain B10.LP/SnJ which carries a contributed Chromosome 2 segment from inbred LP/J. The segment which covers a range from 2 cM distal of Ada to 2 cM proximal of H13 wasLP/J like for Bfq1. The congenic findings indicate that the obese phenotype designated as Bfq1 segregated with distal mouse Chromosome 2 loci during the construction of congenic strain B10.LP/SnJ. Bfq1 quantitative trait locus (QTL) can be placed on mouse Chromosome 2 between cM postions 69 and 94 close to D2Mit513. In a personal communication from Dr. Aamir Zuberi to MGI it was suggested that the obesity phenotype in B10.LP/SnJ may in fact be unrelated to Bfq1.

References
Original:  J:42700 Lembertas AV, et al., Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J Clin Invest. 1997 Sep 1;100(5):1240-7
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory