Bfq1^LP/J
QTL Variant Detail

Summary

• QTL variant: Bfq1^LP/J
• Name: body fat QTL 1; LP/J
• MGI ID: MGI:2155179
• QTL: Bfq1 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: LP/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers decreased body weight, percent body fat, retroperitoneal fat pad weight, and reduced fasting plasma insulin compared to C57BL/10SnJ. (J:42700)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Congenic mice B10.LP-H3^bH13^b/(36NS)Sn carry an LP/J-derived portion of chromosome 2 containing histocompatibility loci H3 and H13 on a C57BL/10SnJ background. These congenics display a 7% decrease in body weight, 66% decrease in retroperitoneal fat pad weight, 35% decrease in percent body fat, and 27% lower fasting plasma insulin.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:42700

A total of 84 female (NZB/BlNJ x SM/J)F2 mice were analyzed for 126 genetic markers covering all mouse chromosomes except for the Y Chromosome. An obesity quantitative trait locus (QTL) Bfq1, was significantly associated with a region of mouse Chromosome2 bounded distally by D2Mit28 and proximally by D2Mit22. Additionally, mouse congenic strain B10.LP/SnJ which carries a contributed Chromosome 2 segment from inbred LP/J. The segment which covers a range from 2 cM distal of Ada to 2 cM proximal of H13 wasLP/J like for Bfq1. The congenic findings indicate that the obese phenotype designated as Bfq1 segregated with distal mouse Chromosome 2 loci during the construction of congenic strain B10.LP/SnJ. Bfq1 quantitative trait locus (QTL) can be placed on mouse Chromosome 2 between cM postions 69 and 94 close to D2Mit513. In a personal communication from Dr. Aamir Zuberi to MGI it was suggested that the obesity phenotype in B10.LP/SnJ may in fact be unrelated to Bfq1.

References

• Original: J:42700 Lembertas AV, et al., Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J Clin Invest. 1997 Sep 1;100(5):1240-7
• All: 1 reference(s)