Afw12^DU6i
QTL Variant Detail

Summary

• QTL variant: Afw12^DU6i
• Name: abdominal fat weight QTL 12; DU6i
• MGI ID: MGI:2155285
• QTL: Afw12 Location: unknown Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: DU6i

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased abdominal fat weight compared to DBA/2.
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Afw12 exhibits an additive mode of inheritance.

Trait Annotation
(using the Vertebrate Trait Ontology)

organism trait

body size trait

body fat mass VT:0010482

affect on abdominal fat weight - J:66233

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66233

QTL effecting body weight, obesity and muscle weight were found on mouse Chromosomes 1, 4, 5, 7, 11, 12, 13, and 17 and for leptin on 14 and insulin on chromosome 4. The cross used in the genome wide scan included approximately 400 F2 mice from a (DU6i xDBA/2)F1 intercross. DU6i is a strain selected for high body weight. 93 microsatellite markers were analyzed in the genome wide scan. Locations of the QTL were provided by the authors and may not be equivalent to the closest microsatellites. Abdominal fat percent QTL 1 was mapped to mouse Chromosome 3 with a cM range from 23 to 37 cM. Abdominal fat weight QTL was mapped to mouse Chromosome 3 position 30 with a range from 23 to 36 cM.

10.03.2014 - Curator Note: We had originally associated the abdominal fat weight QTL identified here, mapping to 30 cM between 23 and 36cM on mouse Chr 3, as Afw1. Afw1 was originally mapped using a different cross, an outbred cross of DU6 x DUK, in J:49578 in 1998. We consider the current mapping study a separate mapping experiment and have named the QTL identified here as Afw12.

04.14.2015 - Curator Note: The abdominal fat percent QTL 1 (Afpq1) was originally mapped in J:49578 in 1998 using DU6 (selected for high body weight) and a DUKs female mice, which differ from the cross used here. We consider the current mapping study a separate mapping experiment and have named the QTL identified here mapping to mouse Chromosome 3 with a cM range from 23 to 37 cM as Apfq7.

References

• Original: J:66233 Brockmann GA, et al., Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice. Genome Res. 2000 Dec;10(12):1941-57
• All: 1 reference(s)