Skull4^SM/J
QTL Variant Detail

Summary

• QTL variant: Skull4^SM/J
• Name: skull morphology 4; SM/J
• MGI ID: MGI:2155359
• QTL: Skull4 Location: Chr3:69625509-69625745 bp Genetic Position: Chr3, cM position of peak correlated region/allele: 32.25 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased size in skull characteristics compared to LG/J.
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53484

76 polymorphic markers at an average spacing of 27.5 cM were screened in 535 F2 animals from a cross between inbred strains LG/J and SM/J to identify QTLs affecting skull morphology characteristics. The LG/J strain has a larger body size than the SM/J strain. A total of 26 skull morphology QTLs were identified. On mouse Chromosome 1, Skull1 maps to 46 cM - 68 cM with LOD = 4.67 at D1Mit7 and Skull2 maps to 104 cM - 134 cM with LOD>3.03 at D1Mit14. On mouse Chromosome 2, Skull3 maps to 69 cM - 78 cM with LOD = 9.32 at D2Mit17. On mouse Chromosome 3, Skull4 maps to 43 cM - 53 cM with LOD = 12.05 at D3Mit22. On mouse Chromosome 4, Skull5 maps to 26 cM - 54 cM with LOD = 6.41 and Skull6 maps to 66 cM - 84 cM with LOD>3.03 at D4Mit16. On mouse Chromosome 6, Skull7 maps to 4 cM - 66 cM with LOD = 8.44 at D6Mit1 and Skull8 maps to 82 cM - 100 cM with LOD>3.03 at D6Nds5. On mouse Chromosome 7, Skull9 maps to 27 cM - 61 cM with LOD = 17.41 at D7Nds1 and Skull10 maps to 61 cM - 105 cM with LOD>3.03 at D7Mit17. Onmouse Chromosome 8, Skull11 maps to 31 cM - 63 cM with LOD = 3.83 at D8Mit8. On mouse chromosome 9, Skull12 maps to 16 cM - 24 cM with LOD = 5.32 at D9Mit2 and Skull13 maps to 48 cM - 74 cM with LOD>3.03 at D9Mit8. On mouse Chromosome 10, Skull14 maps to59cM - 71 cM with LOD = 7.27 at D10Mit20. On mouse Chromosome 11, Skull15 maps to 23 cM - 55 cM with LOD = 5.85 at D11Mit62 and Skull16 maps to 69 cM - 99 cM with LOD>3.03 at D11Mit14. On mouse Chromosome 12, Skull17 maps to 1 cM - 39 cM with LOD = 10.33 at D12Mit37 and Skull18 maps to 47 cM - 63 cM with LOD>3.03 at D12Mit6. On mouse Chromosome 13, Skull19 maps to 7 cM - 41 cM with LOD = 2.95 at D13Mit1 and Skull22 maps to 7 cM - 97 cM with P<0.05 at D13Mit9. On mouse Chromosome 14, Skull21 maps to 28 cM -56 cM with LOD-4.66 at D14Mit5. On mouse Chromosome 15, Skull20 maps to 47 cM - 57 cM with LOD=12.63 at D15Mit15. On mouse Chromosome 16, Skull23 maps to 30 cM - 44 cM with LOD = 3.96 at D16Mit2. On mouse Chromosome 17, Skull 24 maps to 15 cM - 21 cM with LOD = 4.35 at D17Mit46 and Skull25 maps to 21 cM - 57 cM with LOD>3.03 at D17Mit16. On mouse Chromosome 19, Skull26 maps to 15 cM - 21 cM with LOD = 3.55 at D19Mit16.

J:102035

Data from Leamy et al 1999 were reanalyzed to assess loci involved in early and late skull development. The data set includes 535 (LG/J x SM/J)F2 animals. Genome scan was performed with 76 informative markers covering 19 autosomes. Parental strain LG/J exhibits larger body size compared to parental strain SM/J. Early skull development traits phenotyped are cranial vault width, cranial vault height, and cranial vault length. Late skull development traits phenotyped are facial height, width, and length, and zygomatic arch width and length. Loci reaching the 5% significance level are reported below. Loci colocalizing with previously identified QTL from the Leamy et al 1999 study are represented using Skull# symbols. Novel loci are represented by the symbolsSdtq# (skull development trait QTL #). For full descriptions of QTL-trait associations refer to Table 2 of this reference. Most of these loci interact epistatically.

On mouse Chromosome 1, early skull development mapped to 110 cM (Skull2). Late skull development mapped to 52 cM (Skull1) and 92 cM (Sdtq1).

On mouse Chromosome 2, early skull development mapped to 12 cM (Sdtq2) and late skull development mapped to 0 cM (Stdq3).

On mouse Chromosome 3, early and late skull development mapped to 44 cM (Skull4).

On mouse Chromosome 4, early and late skull development mapped to 62 cM (Skull6) and late skull development mapped to 36 cM (Skull5).

On mouse Chromosome 5, early skull development mapped to 104 cM (Stdq4).

On mouse Chromosome 6, early skull development mapped to 30 cM (Skull7), and early and late skull development mapped to 90 cM (Skull8).

On mouse Chromosome 7, early skull development mapped to 24 cM (Sdtq5) and 76 cM (Skull10), and late skull development mapped to 58 cM (Skull9).

On mouse Chromosome 8, late skull development maps to 18 cM (Sdtq6).

On mouse Chromosome 9, early and late skull development map to 46 cM (Skull13) and late skull developme maps to 2 cM (Sdtq7).

On mouse Chromosome 10, early skull development map to 22 cM (Sdtq8)and 44 cM (Sdtq9). Late skull development maps to 64 cM (Skull14).

On mouse Chromosome 11, early skull development maps to 34 cM (Skull15), and early and late skull development maps to 88 cM (Skull16).

On mouse Chromosome 12, early and late skull development map to 8 cM - 30 cM (Skull17) and to 54 cM (Skull18).

On mouse Chromosome 13, early skull development maps to 2 cM (Skull19) and late skull development maps to 70 cM (Skull20).

On mouse Chromosome 14, early and late skull development map to 32 cM- 51 cM (Skull21).

On mouse Chromosome 15, early and late skull development map to 46 cM (Skull22).

On mouse Chromosome 17, early and late skull development map to 6 cM - 8 cM (Sdtq10).

On mouse Chromosome 19, early skull development maps to 26 cM (Skull26) and late skull development maps to 4 cM (Stdq11).

References

• Original: J:53484 Leamy LJ, et al., Quantitative trait loci for early- and late-developing skull characters in mice: a test of the genetic independence model of morphological integration. Am Naturalist. 1999;153(2):201-214
• All: 2 reference(s)