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Etohcta3C57BL/6J
QTL Variant Detail
Summary
QTL variant: Etohcta3C57BL/6J
Name: ethanol conditioned taste aversion 3; C57BL/6J
MGI ID: MGI:2155408
QTL: Etohcta3  Location: unknown  Genetic Position: Chr3, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50271

841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Etohcta3 (P<0.01 at D3Mc1) and Etohcta4 (P<0.01 at Gnat2) mapped to Chromosome 3 at 21 cM and 49 cM, respectively. Etohcta3 and Etohcta4 are associated with ethanol-induced taste aversion at low-dose ethanol injection following the paired taste. Candidate genes on Chromosome 3 include acetylcholine receptor subunits. Taste3(P<0.01 at D3Byu4) mapped to 40.6 cM on Chromosome 3 and is associated with saccharin preference.

References
Original:  J:50271 Risinger FO, et al., Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res. 1998 Sep;22(6):1234-44
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory