Summary |
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Variant origin |
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Variant description |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:50271841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Etohcta3 (P<0.01 at D3Mc1) and Etohcta4 (P<0.01 at Gnat2) mapped to Chromosome 3 at 21 cM and 49 cM, respectively. Etohcta3 and Etohcta4 are associated with ethanol-induced taste aversion at low-dose ethanol injection following the paired taste. Candidate genes on Chromosome 3 include acetylcholine receptor subunits. Taste3(P<0.01 at D3Byu4) mapped to 40.6 cM on Chromosome 3 and is associated with saccharin preference. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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